EVIDENCE ON THE CARCINOGENICITY OF 5-CHLORO-O-TOLUIDINE AND ITS STRONG ACID SALTS Reproductive and Cancer Hazard Assessment Section Office of Environmental Health Hazard Assessment California Environmental Protection Agency
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چکیده
PREFACE The Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65, California Health and Safety Code 25249.5 et seq.) requires that the Governor cause to be published a list of those chemicals " known to the state " to cause cancer or reproductive toxicity. The Act specifies that " a chemical is known to the state to cause cancer or reproductive toxicity...if in the opinion of the state's qualified experts the chemical has been clearly shown through scientifically valid testing according to generally accepted principles to cause cancer or reproductive toxicity. " The lead agency for implementing Proposition 65 is the Office of Environmental Health Hazard Assessment of the California Environmental Protection Agency. The " state's qualified experts " regarding findings of carcinogenicity are identified as the members of the Carcinogen Identification Committee of the OEHHA Science Advisory Board (22 CCR 12301). 5-Chloro-o-toluidine was discussed as a high priority candidate for Committee review during a public committee meeting held in Sacramento, California, on July 22, 1996 and at a public workshop held November 15, 1996. Public input was solicited on the priority of this chemical in two public comment periods, each of 60 days duration. Once the chemical was selected for Committee review, a public request for pertinent information was made. This draft document Evidence on the Carcinogenicity of 5-Chloro-o-Toluidine and Its Strong Acid Salts was developed to provide the Committee with relevant information for use in its deliberations, and reviews the available scientific evidence on the carcinogenic potential of 5-chloro-o toluidine and its strong acid salts. The meeting where the Committee is to discuss this evidence has been tentatively scheduled for September 25, 1997. 5-Chloro-o-toluidine (CAS number 95-79-4) and its hydrochloride salt are used in dye-stuff manufacture, as chemical intermediates in the synthesis of other dyes, and as dyes for cotton, silk, nylon and cellulose. Strong acid salts of 5-chloro-o-toluidine, including the hydrochloride, can be expected to exist in a dissociated state in solution and in vivo, and thus are considered toxicologically equivalent to the free or protonated amine forms. 5-Chloro-o toluidine has been shown to induce tumors at multiple sites in both sexes of the mouse when administered in the diet. A high incidence of hemangiosarcomas, a relatively uncommon tumor of the vasculature, was observed in both male and female mice. Significantly increased incidences of hepatocellular carcinomas and hepatocellular carcinomas and adenomas (combined) were also observed …
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